Ap3m1 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Involved in anterograde synaptic vesicle transport and postsynaptic neurotransmitter receptor internalization. Is active in postsynaptic recycling endosome. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap3m1 |
| Official Name | adaptor-related protein complex 3, mu 1 subunit [Source:MGI Symbol;Acc:MGI:1929212] |
| Ensembl ID | ENSMUSG00000021824 |
| Bio databases IDs | |
| Aliases | adaptor-related protein complex 3, mu 1 subunit |
| Synonyms | 1200013D09Rik, adaptor-related protein complex 3, mu 1 subunit, adaptor related protein complex 3 subunit mu 1, AP-3 adapter complex mu3A, Ap-3 m3, AP-3 mu3, AP4M3A, P47a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap3m1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clathrin adaptor complex small chain
- AP_MHD_Cterm
- APS2
- enzyme binding
- Adaptor complexes medium subunit family
- protein binding
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the Ap3m1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- lysosome
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap3m1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- vesicle-mediated transport
- anterograde axon cargo transport
- intracellular transport
- endocytosis
- protein targeting to lysosome
- cargo loading into clathrin-coated vesicle, AP-3-mediated
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasmic vesicle membrane
- cytoplasmic vesicle
- clathrin adaptor complex
- AP-3 adaptor complex
- Golgi apparatus
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding