Cnmd Gene Summary [Mouse]

Acts upstream of or within several processes, including endothelial cell morphogenesis; negative regulation of endothelial cell proliferation; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart valve; sensory organ; and skeleton. Orthologous to human CNMD (chondromodulin). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Cnmd
Official Name
chondromodulin [Source:MGI Symbol;Acc:MGI:1341171]
Ensembl ID
ENSMUSG00000022025
Bio databases IDs NCBI: 16840 Ensembl: ENSMUSG00000022025
Aliases chondromodulin
Synonyms BRICD3, CHM1, Chmd, CHM-I, chondromodulin, LECT1, MYETS1
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnmd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Pulmonary surfactant proteins
  • protein binding
  • BRICHOS domain

Pathways

Biological processes and signaling networks where the Cnmd gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • osteosarcomagenesis
  • Ewing sarcoma
  • synovial sarcoma
  • soft tissue sarcoma cancer
regulated by
regulates
role in cell
  • proliferation
  • development
  • function
  • morphogenesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Cytoplasm
  • cartilage matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnmd gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of angiogenesis
  • skeletal system development
  • cell differentiation
  • negative regulation of endothelial cell proliferation
  • proteoglycan metabolic process
  • cartilage development

Cellular Component

Where in the cell the gene product is active
  • membrane
  • endomembrane system
  • extracellular region

Gene-Specific Assays for Results You Can Trust

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