Socs4 Gene Summary [Mouse]
Predicted to be involved in cytokine-mediated signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Is expressed in ganglia; sensory organ; thymus primordium; and ventricular layer. Orthologous to human SOCS4 (suppressor of cytokine signaling 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Socs4 |
| Official Name | suppressor of cytokine signaling 4 [Source:MGI Symbol;Acc:MGI:1914546] |
| Ensembl ID | ENSMUSG00000048379 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 4 |
| Synonyms | 2310063P06RIK, 3110032M18Rik, A730004F22RIK, NAP4, SOCS-6, SOCS7, suppressor of cytokine signaling 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Socs4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- SOCS
- Src homology 2 (SH2) domain
- protein binding
- Suppressor of cytokine signalling
Pathways
Biological processes and signaling networks where the Socs4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- glioblastoma
- glioblastoma cancer
- high grade glioma
- glioma cancer
role in cell
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Socs4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epidermal growth factor-activated receptor activity
- phosphatidylinositol phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- 1-phosphatidylinositol-3-kinase regulator activity