Appl2 Gene Summary [Mouse]
Predicted to enable phospholipid binding activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including adiponectin-activated signaling pathway; negative regulation of metabolic process; and positive regulation of endocytosis. Located in early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; brain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Appl2 |
| Official Name | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 [Source:MGI Symbol;Acc:MGI:2384914] |
| Ensembl ID | ENSMUSG00000020263 |
| Bio databases IDs | |
| Aliases | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 |
| Synonyms | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2, DIP13B, DIP13 beta, DIP13 β, DIP3B, Dip3 beta, Dip3 β, RGD1563028 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Appl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- BAR domain of APPL family
- binding protein
- PH domain
- enzyme binding
- protein homodimerization
- protein binding
- Pleckstrin homology-like domain
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Appl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
role in cell
- activation in
- proliferation
- function
- signaling in
- migration
- invasion by
- binding in
- migration by
- phagocytosis by
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- membrane ruffles
- endosomal membrane
- cytoplasmic vesicles
- phagosomes
- macropinosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Appl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phagocytosis, engulfment
- signal transduction
- regulation of toll-like receptor 4 signaling pathway
- negative regulation of cellular response to insulin stimulus
- negative regulation of glucose import
- transforming growth factor beta receptor signaling pathway
- negative regulation of cytokine production involved in inflammatory response
- cold acclimation
- diet induced thermogenesis
- protein homotetramerization
- negative regulation of fatty acid oxidation
- cellular response to hepatocyte growth factor stimulus
- protein import into nucleus
- regulation of innate immune response
- signaling
- glucose homeostasis
- negative regulation of neural precursor cell proliferation
- negative regulation of neurogenesis
- regulation of G1/S transition of mitotic cell cycle
- adiponectin-mediated signaling pathway
- regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- early phagosome membrane
- macropinosome
- plasma membrane
- early endosome membrane
- nucleus
- early phagosome
- extracellular vesicular exosome
- endosome
- membrane
- ruffle
- vesicle
- cytoplasmic vesicle
- ruffle membrane
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- identical protein binding
- protein homodimerization activity
- protein binding
- phosphatidylinositol binding