Bin3 Gene Summary [Mouse]
Predicted to contribute to lipid binding activity. Acts upstream of or within myoblast migration involved in skeletal muscle regeneration; regulation of lamellipodium assembly; and skeletal muscle fiber development. Located in actin cytoskeleton. Is expressed in several structures, including 1st branchial arch; lens; limb; and testis. Orthologous to human BIN3 (bridging integrator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bin3 |
| Official Name | bridging integrator 3 [Source:MGI Symbol;Acc:MGI:1929883] |
| Ensembl ID | ENSMUSG00000022089 |
| Bio databases IDs | |
| Aliases | bridging integrator 3 |
| Synonyms | 1700015F07Rik, bridging integrator 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bin3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BAR domain
- Bin/Amphiphysin/Rvs domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- lipopolysaccharide
- hepatitis B virus
- testosterone
- alpha 1 antitrypsin
disease
- neoplasia
- lung cancer
- cataract disease
- cancer
- epithelial cancer
- epithelial neoplasia
- lymphomagenesis
- non-insulin-dependent diabetes mellitus
- breast carcinoma
- hematologic cancer
role in cell
- growth
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bin3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
- regulation of lamellipodium assembly
- unidimensional cell growth
- barrier septum assembly
- skeletal muscle fiber development
- myoblast migration involved in skeletal muscle regeneration
- protein localization
- actin filament organization
- endocytosis
- actin cortical patch localization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- cytoskeletal adaptor activity
- protein binding
- lipid binding