Tjp1 Gene Summary [Mouse]
Enables connexin binding activity and protein domain specific binding activity. Involved in several processes, including ameloblast differentiation; negative regulation of stress fiber assembly; and positive regulation of sprouting angiogenesis. Acts upstream of or within blastocyst formation and sensory perception of sound. Located in several cellular components, including apicolateral plasma membrane; bicellular tight junction; and intercellular canaliculus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tjp1 |
| Official Name | tight junction protein 1 [Source:MGI Symbol;Acc:MGI:98759] |
| Ensembl ID | ENSMUSG00000030516 |
| Bio databases IDs | |
| Aliases | tight junction protein 1 |
| Synonyms | Gm1693, tight junction protein 1, ZO-1, zona occludens 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tjp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- beta-catenin binding
- canonical PDZ domain
- protein domain specific binding
- ZO-1 binding domain
- protein binding
- PDZ domain
- ZU5 domain
- DLG binding domain
- Src Homology 3 domain superfamily
- PSD 95 binding domain
- actin-binding domain
- NK
- ion channel binding
- cpPDZ_Deg_HtrA-like
- PDZ binding motif
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Tjp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- leukemia
- metastasis
- T-cell non-Hodgkin disease
- arrhythmogenic right ventricular cardiomyopathy
- organismal death
- peripheral T-cell lymphoma
- mature T-cell neoplasia
- Huntington disease
- lung adenocarcinoma
role in cell
- quantity
- expression in
- proliferation
- apoptosis
- area
- migration
- growth
- density
- invasion
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- basal ectoplasmic specialization of blood-testis barrier
- nuclear fraction
- detergent-insoluble fractions
- membrane fraction
- button-like junction
- apicolateral membrane
- cell junction
- Cytoplasm
- cell surface
- cell borders
- perijunctional region
- cell periphery
- apical compartment
- basal compartment
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- Mitochondria
- actin filaments
- midbody
- intercellular junctions
- endothelial paracellular clefts
- cell-cell contacts
- cytosol
- basal cell surfaces
- lateral cell surfaces
- apical cell surfaces
- caveolar membranes
- apical membrane
- basolateral membrane
- lateral plasma membrane
- paranodal loops
- synapse
- pedicels
- Schmidt-Lanterman incisures
- intercalated disks
- cytoplasmic vesicles
- anchoring junction
- gap junctions
- tight junctions
- junctional complexes
- apical cell-cell contacts
- lateral cell-cell contacts
- perikaryon
- axon terminals
- cell-cell adherens junctions
- plasma
- podocyte slit diaphragm
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tjp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell junction assembly
- actomyosin structure organization
- positive regulation of cell proliferation
- cell-cell junction organization
- negative regulation of stress fiber assembly
- negative regulation of apoptotic process
- regulation of cytoskeleton organization
- adherens junction maintenance
- protein localization to adherens junction
- regulation of tight junction assembly
- actin cytoskeleton organization
- maintenance of blood-brain barrier
- positive regulation of cell-cell adhesion mediated by cadherin
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell projection
- plasma membrane
- podosome
- gap junction
- tight junction
- adherens junction
- occluding junction
- apical part of cell
- cytoplasm
- apical junction complex
- cell junction
- cytosol
- macromolecular complex
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- cadherin binding
- cell adhesion molecule binding