Fbxo8 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Is expressed in several structures, including branchial arch; ear; forelimb bud; heart; and notochord. Orthologous to human FBXO8 (F-box protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fbxo8 |
| Official Name | F-box protein 8 [Source:MGI Symbol;Acc:MGI:1354696] |
| Ensembl ID | ENSMUSG00000038206 |
| Bio databases IDs | |
| Aliases | F-box protein 8 |
| Synonyms | DC10, F-box protein 8, FBS, FBX8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- Sec7
- Sec7 domain
- F-box-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity