Polr1c Gene Summary [Mouse]
Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; genitourinary system; midbrain; respiratory system; and telencephalon. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr1c |
| Official Name | polymerase (RNA) I polypeptide C [Source:MGI Symbol;Acc:MGI:103288] |
| Ensembl ID | ENSMUSG00000067148 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) I polypeptide C |
| Synonyms | Ac2-127, AC40, AL024089, HLD11, Polr1e, polymerase (RNA) I polypeptide C, RNA polymerase I and III subunit C, RPA39, RPA40, RPA5, RPAC1, RPC40, RPO1-1, TCS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerases D
- DNA-directed RNA polymerase
- RNA polymerase Rpb3/Rpb11 dimerization domain
- enzyme
- protein binding
- RNA polymerase Rpb3/RpoA insert domain
- RPB11 and RPB3 subunits of RNA polymerase
Pathways
Biological processes and signaling networks where the Polr1c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- hypomyelinating leukodystrophy type 11
- Treacher Collins syndrome type 3
- Treacher Collins-Franceschetti syndrome
- colorectal adenoma
- colorectal adenoma formation
- complete testicular feminization syndrome
role in cell
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- cytoplasm
- cytosol
- fibrillar center
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase III activity
- protein binding
- RNA polymerase I activity
- DNA-directed RNA polymerase activity
- protein dimerization activity