Rab2b Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Involved in defense response to other organism; macroautophagy; and positive regulation of type I interferon production. Located in Golgi apparatus; acrosomal vesicle; and autophagosome membrane. Is expressed in nervous system. Orthologous to human RAB2B (RAB2B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab2b |
| Official Name | RAB2B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1923588] |
| Ensembl ID | ENSMUSG00000022159 |
| Bio databases IDs | |
| Aliases | RAB2B, member RAS oncogene family |
| Synonyms | 1500012D09RIK, 4930528G15RIK, A230002G14, D530043M21RIK, RAB2B, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- Golgi Apparatus
- acrosome
- autophagic vacuoles
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- Golgi organization
- innate immune response
- positive regulation of type I interferon production
- protein transport
- defense response to virus
- macroautophagy
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- acrosomal vesicle
- Golgi membrane
- Golgi apparatus
- plasma membrane
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity