Fam114a1 Gene Summary [Mouse]
Acts upstream of or within several processes, including angiotensin-activated signaling pathway; fibroblast activation; and fibroblast migration. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Is expressed in Meckel's cartilage and cranium. Orthologous to human FAM114A1 (family with sequence similarity 114 member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam114a1 |
| Official Name | family with sequence similarity 114, member A1 [Source:MGI Symbol;Acc:MGI:1915553] |
| Ensembl ID | ENSMUSG00000029185 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 114, member A1 |
| Synonyms | 1190001N04Rik, 9130005N14Rik, CDNA FLJ33151 FIS, family with sequence similarity 114 member A1, family with sequence similarity 114, member A1, FLJ33151 FIS, Noxp20, RGD1560201 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam114a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF719)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diarrhea
- cardiac fibrosis
- heart failure
- non-small cell lung carcinoma
- non-small cell lung cancer
- restless legs syndrome
- alcoholism
- cardiac hypertrophy
regulated by
- lactic acid
- levodopa
- NUPR1
regulates
- ERK1/2
- AKT
- p38 MAPK
- angiotensin II receptor type 1
role in cell
- proliferation
- expression in
- phosphorylation in
- migration
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam114a1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding