Zfyve27 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Involved in positive regulation of axon extension and vesicle-mediated transport. Located in dendrite; endoplasmic reticulum tubular network; and growth cone membrane. Is expressed in ganglia; genitourinary system; sensory organ; and vibrissa. Orthologous to human ZFYVE27 (zinc finger FYVE-type containing 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zfyve27 |
| Official Name | zinc finger, FYVE domain containing 27 [Source:MGI Symbol;Acc:MGI:1919602] |
| Ensembl ID | ENSMUSG00000018820 |
| Bio databases IDs | |
| Aliases | zinc finger, FYVE domain containing 27 |
| Synonyms | 2210011N02RIK, 9530077C24Rik, AI426636, PROTRUDIN, SPG33, zinc finger, FYVE domain containing 27, zinc finger FYVE-type containing 27 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfyve27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- Protein present in Fab1, YOTB, Vac1, and EEA1
- FFAT motif
- PHD finger superfamily
- coiled-coil domain
- protein binding
- identical protein binding
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperactive behavior
- hereditary spastic paraplegia autosomal dominant 33
- preeclampsia
role in cell
- binding in
- degradation in
- formation
- morphogenesis
- outgrowth
- invasion by
- degradation by
- exocytosis by
- formation in
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- endoplasmic reticulum tubules
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endosomal membrane
- nucleoplasm
- growth cone
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfyve27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nerve growth factor receptor signaling pathway
- vesicle-mediated transport
- neuron projection development
- endoplasmic reticulum tubular network assembly
- positive regulation of axon extension
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- intracellular membrane-bounded organelle
- endoplasmic reticulum tubular network
- cytosol
- growth cone membrane
- endoplasmic reticulum
- recycling endosome membrane
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding