Ripk3 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and positive regulation of necroptotic process. Acts upstream of or within with a positive effect on non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; and regulation of reactive oxygen species metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; immune system; male reproductive gland or organ; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ripk3 |
| Official Name | receptor-interacting serine-threonine kinase 3 [Source:MGI Symbol;Acc:MGI:2154952] |
| Ensembl ID | ENSMUSG00000022221 |
| Bio databases IDs | |
| Aliases | receptor-interacting serine-threonine kinase 3 |
| Synonyms | 2610528K09Rik, HCYP2, receptor interacting serine/threonine kinase 3, receptor-interacting serine-threonine kinase 3, RIP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ripk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- transcription co-activator
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- RIP homotypic interaction motif
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- splenomegaly
- anemia
- pancreatitis
- ileitis
- inflammatory bowel disease
- systemic lupus erythematosus
- laser induced choroidal neovascularization
- complete testicular feminization syndrome
- lung metastasis
- retinal neovascularization
role in cell
- phosphorylation in
- number
- apoptosis
- expression in
- proliferation
- survival
- growth
- cellular infiltration by
- cell death
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intracellular space
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ripk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- spleen development
- protein autophosphorylation
- apoptotic signaling pathway
- lymph node development
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of necroptosis
- thymus development
- T cell homeostasis
- regulation of interferon-gamma production
- programmed necrotic cell death
- necroptosis
- positive regulation of transcription, DNA-dependent
- defense response to virus
- activation of protein kinase activity
- regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
- cellular response to hydrogen peroxide
- regulation of adaptive immune response
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of reactive oxygen species metabolic process
- T cell differentiation in thymus
- signal transduction
- regulation of activated T cell proliferation
- NIK/NF-kappaB cascade
- regulation of apoptotic process
- reactive oxygen species metabolic process
- positive regulation of phosphatase activity
- regulation of T cell mediated cytotoxicity
- regulation of activation-induced cell death of T cells
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- transcription coactivator activity
- protein kinase activity
- protein serine/threonine kinase activity