Fadd

Enables signaling adaptor activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; and regulation of apoptotic process. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and negative regulation of necroptotic process. Predicted to be located in cell body; cytosol; and plasma membrane. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in immunodeficiency 90 and leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fadd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Fadd gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fadd gene, providing context for its role in the cell.