RIPK3 Gene Summary [Human]
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RIPK3 |
| Official Name | receptor interacting serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:10021] |
| Ensembl ID | ENSG00000129465 |
| Bio databases IDs | |
| Aliases | receptor interacting serine/threonine kinase 3 |
| Synonyms | 2610528K09Rik, HCYP2, receptor interacting serine/threonine kinase 3, receptor-interacting serine-threonine kinase 3, RIP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RIPK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- transcription co-activator
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- RIP homotypic interaction motif
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- splenomegaly
- anemia
- pancreatitis
- ileitis
- inflammatory bowel disease
- systemic lupus erythematosus
- laser induced choroidal neovascularization
- complete testicular feminization syndrome
- lung metastasis
- retinal neovascularization
role in cell
- phosphorylation in
- number
- apoptosis
- expression in
- proliferation
- survival
- growth
- cellular infiltration by
- cell death
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intracellular space
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RIPK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- spleen development
- protein autophosphorylation
- apoptotic signaling pathway
- lymph node development
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of necroptosis
- thymus development
- T cell homeostasis
- regulation of interferon-gamma production
- programmed necrotic cell death
- necroptosis
- positive regulation of transcription, DNA-dependent
- defense response to virus
- activation of protein kinase activity
- regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
- cellular response to hydrogen peroxide
- regulation of adaptive immune response
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of reactive oxygen species metabolic process
- T cell differentiation in thymus
- signal transduction
- regulation of activated T cell proliferation
- NIK/NF-kappaB cascade
- regulation of apoptotic process
- reactive oxygen species metabolic process
- positive regulation of phosphatase activity
- regulation of T cell mediated cytotoxicity
- regulation of activation-induced cell death of T cells
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- transcription coactivator activity
- protein kinase activity
- protein serine/threonine kinase activity