Dnah5 Gene Summary [Mouse]
Enables microtubule motor activity. Acts upstream of or within several processes, including determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and lateral ventricle development. Located in axoneme; glial cell projection; and motile cilium. Part of outer dynein arm. Is expressed in several structures, including epithelium; gut; male reproductive gland or organ; and midbrain. Used to study otitis media; primary ciliary dyskinesia (multiple); tetralogy of Fallot; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnah5 |
| Official Name | dynein, axonemal, heavy chain 5 [Source:MGI Symbol;Acc:MGI:107718] |
| Ensembl ID | ENSMUSG00000022262 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, heavy chain 5 |
| Synonyms | AU022615, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b601Clo, CILD3, DLP5, DNAHC5, Dnahc8, dynein axonemal heavy chain 5, dynein, axonemal, heavy chain 5, HL1, KTGNR, Mdnah5, mKIAA1603, PCD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnah5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynein heavy chain C-terminal domain
- ATP-binding dynein motor region
- F-type ATP synthase, membrane subunit b
- Microtubule-binding stalk of dynein motor
- enzyme
- protein binding
- AAA+ lid domain
- microtubule motor protein
- Dynein heavy chain, N-terminal region 1
- P-loop containing dynein motor region
- Dynein heavy chain, N-terminal region 2
- P-loop containing dynein motor region D4
- Dynein heavy chain AAA lid domain
- AAA domain (dynein-related subfamily)
- Dynein heavy chain region D6 P-loop domain
- Hydrolytic ATP binding site of dynein motor region
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Axonemal Dynein Outer Arm
- DNAH6
disease
- nasopharyngeal cancer
- primary ciliary dyskinesia 3
- primary ciliary dyskinesia
- nasopharyngeal carcinoma
- epithelial cancer
- infertility condition
- hereditary disorder
- seasonal allergic rhinitis
- sarcomatoid cancer
- chronic obstructive pulmonary disease
phenotypes
- preweaning lethality incomplete penetrance
- abdominal situs ambiguus
- abdominal situs inversus
- abnormal aortic arch morphology
- abnormal atrioventricular cushion morphology
- abnormal cardiovascular system physiology
- abnormal digestive organ placement
- abnormal gait
- abnormal head morphology
- abnormal hearing physiology
- abnormal heart atrium and ventricle connection
- abnormal heart development
- abnormal heart morphology
- abnormal inferior vena cava morphology
- abnormal kidney morphology
- abnormal liver morphology
- abnormal midgut morphology
- abnormal pancreas morphology
- abnormal respiratory motile cilium morphology
- abnormal respiratory motile cilium physiology
- abnormal right subclavian artery morphology
- abnormal spleen morphology
- absent spleen
- anomalous pulmonary venous connection
- atrioventricular septal defect
- biventricular ambiguous atrioventricular connection
- biventricular discordant atrioventricular connection
- cerebellum atrophy
- common atrioventricular valve
- common atrium
- complete atrioventricular septal defect
- dextrocardia
- domed cranium
- double outlet right ventricle
- double outlet right ventricle with atrioventricular septal defect
- dual inferior vena cava
- duplex kidney
- enlarged cranium
- enlarged lateral ventricles
- heart left ventricle hypertrophy
- heart right ventricle hypertrophy
- heart right ventricle hypoplasia
- heterotaxia
- hydrocephaly
- hydronephrosis
- immotile respiratory cilia
- increased susceptibility to otitis media
- interrupted aortic arch
- kidney cysts
- left atrial isomerism
- left pulmonary isomerism
- lethality at weaning complete penetrance
- lung situs inversus
- mesocardia
- micrognathia
- ostium secundum atrial septal defect
- perinatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality
- pulmonary artery hypoplasia
- renal hypoplasia
- respiratory distress
- right aortic arch
- right atrial isomerism
- right-sided stomach
- short snout
- sinus inflammation
- situs inversus
- situs inversus totalis
- situs inversus with levocardia
- superior-inferior ventricles
- thin cerebral cortex
- total anomalous pulmonary venous connection
- transposition of great arteries
- vascular ring
- ventricular septal defect
role in cell
- movement
- assembly
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- axonemes
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnah5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- lateral ventricle development
- outer dynein arm assembly
- sperm motility
- cilium morphogenesis
- cilium movement involved in cell motility
- epithelial cilium movement
- cilium movement
- establishment of localization in cell
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- motile cilium
- outer dynein arm
- cytoplasm
- extracellular region
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- dynein light intermediate chain binding
- minus-end-directed microtubule motor activity
- dynein intermediate chain binding