Dnah5 Gene Summary [Mouse]
Enables microtubule motor activity. Acts upstream of or within several processes, including determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and lateral ventricle development. Located in axoneme; glial cell projection; and motile cilium. Part of outer dynein arm. Is expressed in several structures, including epithelium; gut; male reproductive gland or organ; and midbrain. Used to study otitis media; primary ciliary dyskinesia (multiple); tetralogy of Fallot; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnah5 |
| Official Name | dynein, axonemal, heavy chain 5 [Source:MGI Symbol;Acc:MGI:107718] |
| Ensembl ID | ENSMUSG00000022262 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, heavy chain 5 |
| Synonyms | AU022615, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b601Clo, CILD3, DLP5, DNAHC5, Dnahc8, dynein axonemal heavy chain 5, dynein, axonemal, heavy chain 5, HL1, KTGNR, Mdnah5, mKIAA1603, PCD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnah5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynein heavy chain C-terminal domain
- ATP-binding dynein motor region
- F-type ATP synthase, membrane subunit b
- Microtubule-binding stalk of dynein motor
- enzyme
- protein binding
- AAA+ lid domain
- microtubule motor protein
- Dynein heavy chain, N-terminal region 1
- P-loop containing dynein motor region
- Dynein heavy chain, N-terminal region 2
- P-loop containing dynein motor region D4
- Dynein heavy chain AAA lid domain
- AAA domain (dynein-related subfamily)
- Dynein heavy chain region D6 P-loop domain
- Hydrolytic ATP binding site of dynein motor region
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nasopharyngeal cancer
- primary ciliary dyskinesia 3
- primary ciliary dyskinesia
- nasopharyngeal carcinoma
- epithelial cancer
- infertility condition
- hereditary disorder
- seasonal allergic rhinitis
- sarcomatoid cancer
- chronic obstructive pulmonary disease
regulates
- Axonemal Dynein Outer Arm
- DNAH6
role in cell
- movement
- assembly
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- axonemes
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnah5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- lateral ventricle development
- outer dynein arm assembly
- sperm motility
- cilium morphogenesis
- cilium movement involved in cell motility
- epithelial cilium movement
- cilium movement
- establishment of localization in cell
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- motile cilium
- outer dynein arm
- cytoplasm
- extracellular region
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- dynein light intermediate chain binding
- minus-end-directed microtubule motor activity
- dynein intermediate chain binding