Dnah6 Gene Summary [Mouse]
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; and node. Orthologous to human DNAH6 (dynein axonemal heavy chain 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnah6 |
| Official Name | dynein, axonemal, heavy chain 6 [Source:MGI Symbol;Acc:MGI:107744] |
| Ensembl ID | ENSMUSG00000052861 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, heavy chain 6 |
| Synonyms | 9830168K20, A730004I20Rik, axo a, DNAHC6, DNHL1, dynein axonemal heavy chain 6, dynein, axonemal, heavy chain 6, FLJ37357, HL-2, LOC103690732, LOC200383, mdhc6, mKIAA1697 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnah6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynein heavy chain, N-terminal region 2
- P-loop containing dynein motor region D4
- Dynein heavy chain AAA lid domain
- AAA domain (dynein-related subfamily)
- Dynein heavy chain C-terminal domain
- ATP-binding dynein motor region
- Dynein heavy chain region D6 P-loop domain
- Hydrolytic ATP binding site of dynein motor region
- Microtubule-binding stalk of dynein motor
- AAA+ lid domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- P-loop containing dynein motor region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- idiopathic scoliosis
- primary ciliary dyskinesia type 45
- mixed sarcomatoid-epithelial nasopharyngeal carcinoma
- mixed neoplasia
- sarcomatoid cancer
- nasopharyngeal cancer
- hypospadia
- late-onset Alzheimer disease
- focal segmental glomerulosclerosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnah6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium movement involved in cell motility
Cellular Component
Where in the cell the gene product is active
- dynein complex
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- dynein light intermediate chain binding
- minus-end-directed microtubule motor activity
- dynein intermediate chain binding