Pacsin3 Gene Summary [Mouse]
Enables calcium channel inhibitor activity; cytoskeletal protein binding activity; and lipid binding activity. Involved in negative regulation of calcium ion transport and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human PACSIN3 (protein kinase C and casein kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pacsin3 |
| Official Name | protein kinase C and casein kinase substrate in neurons 3 [Source:MGI Symbol;Acc:MGI:1891410] |
| Ensembl ID | ENSMUSG00000027257 |
| Bio databases IDs | |
| Aliases | protein kinase C and casein kinase substrate in neurons 3 |
| Synonyms | 4921507A02Rik, 6330413E15Rik, protein kinase C and casein kinase substrate in neurons 3, SDPIII |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pacsin3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium channel inhibitor
- lipid binding
- cytoskeletal protein binding
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Plasma Membrane
- granules
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pacsin3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
- negative regulation of endocytosis
- positive regulation of membrane protein ectodomain proteolysis
- cytoskeleton organization
- negative regulation of calcium ion transport
- regulation of endocytosis
- endocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- endosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding
- cytoskeletal protein binding
- phospholipid binding
- calcium channel inhibitor activity