Rnf19a Gene Summary [Mouse]
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Is active in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Orthologous to human RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf19a |
| Official Name | ring finger protein 19A [Source:MGI Symbol;Acc:MGI:1353623] |
| Ensembl ID | ENSMUSG00000022280 |
| Bio databases IDs | |
| Aliases | ring finger protein 19A |
| Synonyms | DORFIN, LOC102724867, ring finger protein 19A, ring finger protein 19A, RBR E3 ubiquitin protein ligase, RNF19, Ubce7ip2, UIP117, XYbp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf19a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBR domain, a half RING-finger domain
- In Between Ring fingers
- substrate recognition sequence
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- BRcat_Rcat_RBR
- enzyme
- Ring finger domain
- protein binding
- cytosolic tail domain
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Rnf19a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast carcinoma
- rheumatoid arthritis
- non-melanoma skin cancer
role in cell
- cell death
- ubiquitination in
- quantity
- olaparib sensitivity
- binding in
- organization
- homologous recombination repair in
- TAK-901 sensitivity
- BI-2536 sensitivity
- JG-231 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- glutaminergic synapse
- centrosome
- cytosol
- XY bodies
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf19a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- microtubule cytoskeleton organization
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- ubiquitin ligase complex
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ubiquitin conjugating enzyme binding
- protein binding