Ikzf1 Gene Summary [Mouse]
The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | Ikzf1 |
| Official Name | IKAROS family zinc finger 1 [Source:MGI Symbol;Acc:MGI:1342540] |
| Ensembl ID | ENSMUSG00000018654 |
| Bio databases IDs | |
| Aliases | IKAROS family zinc finger 1 |
| Synonyms | 5832432G11Rik, CVID13, hlk-1, Hs.54452, Ik, Ik1, IKAROS, IKAROS family zinc finger 1, LOC100132224, LOC389490, LYF1, mKIAA4227, PPP1R92, PRO0758, RGD1562979, Zfpn1a1, ZNFN1A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ikzf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- CtBP binding domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- C2H2-type zinc-finger domain
- linker domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- poly-pyrimidine tract binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Ikzf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- cancer
- respiratory disorder
- lymphoma
- systemic lupus erythematosus
- hyperplasia
- insulin-dependent diabetes mellitus
- anemia
- diabetic nephropathy
- androgenic alopecia
phenotypes
- abnormal B cell activation
- abnormal B cell differentiation
- abnormal B cell number
- abnormal NK cell morphology
- abnormal T cell differentiation
- abnormal common myeloid progenitor cell morphology
- abnormal definitive hematopoiesis
- abnormal dendritic cell morphology
- abnormal dendritic cell number
- abnormal eosinophil morphology
- abnormal erythroblast morphology
- abnormal erythroid progenitor cell morphology
- abnormal erythropoiesis
- abnormal granulocyte differentiation
- abnormal gut flora balance
- abnormal immune system organ morphology
- abnormal lymph node cortex morphology
- abnormal lymph node medulla morphology
- abnormal lymphopoiesis
- abnormal macrophage differentiation
- abnormal myelopoiesis
- abnormal natural killer cell mediated cytotoxicity
- abnormal peripheral lymph node morphology
- abnormal spleen morphology
- abnormal splenic cell ratio
- abnormal thymocyte activation
- abnormal thymus cortex morphology
- abnormal thymus development
- abnormal thymus lobule morphology
- abnormal thymus medulla morphology
- abnormal thymus morphology
- absent B cells
- absent B-1a cells
- absent NK cells
- absent Peyer's patches
- absent T cells
- absent axillary lymph nodes
- absent cervical lymph nodes
- absent inguinal lymph nodes
- absent mesenteric lymph nodes
- absent pre-B cells
- absent pro-B cells
- anemia
- arrested B cell differentiation
- arrested T cell differentiation
- decreased B cell number
- decreased B cell proliferation
- decreased B-1a cell number
- decreased B-1b cell number
- decreased CD4-positive CD25-positive alpha-beta regulatory T cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased DN1 thymic pro-T cell number
- decreased DN2 thymocyte number
- decreased DN3 thymocyte number
- decreased IgG3 level
- decreased T cell number
- decreased body size
- decreased bone marrow cell number
- decreased double-negative T cell number
- decreased double-positive T cell number
- decreased erythrocyte cell number
- decreased erythroid progenitor cell number
- decreased fetal derived definitive erythrocyte cell number
- decreased gamma-delta intraepithelial T cell number
- decreased granulocyte number
- decreased heart rate
- decreased hematocrit
- decreased hemoglobin content
- decreased immature B cell number
- decreased mature B cell number
- decreased mature gamma-delta T cell number
- decreased plasmacytoid dendritic cell number
- decreased pre-B cell number
- decreased pre-pro B cell number
- decreased single-positive T cell number
- decreased spleen germinal center number
- decreased spleen red pulp amount
- decreased splenocyte number
- decreased thymocyte number
- enhanced humoral immune response
- enlarged cervical lymph nodes
- enlarged lymph nodes
- enlarged mesenteric lymph nodes
- enlarged spleen
- enlarged thymus
- extramedullary hematopoiesis
- increased B cell number
- increased B-1 B cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgG level
- increased T cell derived lymphoma incidence
- increased T cell number
- increased T cell proliferation
- increased basophil cell number
- increased central memory CD4-positive alpha-beta T cell number
- increased central memory CD8 positive alpha-beta T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased gamma-delta T cell number
- increased leukemia incidence
- increased lymphoma incidence
- increased macrophage cell number
- increased nucleated erythrocyte cell number
- increased pre-B cell number
- increased pro-B cell number
- increased response to antigen
- increased single-positive T cell number
- increased spleen white pulp amount
- increased susceptibility to bacterial infection
- intermingled spleen red and white pulp
- lethality throughout fetal growth and development complete penetrance
- lethality complete penetrance
- liver hypoplasia
- lung inflammation
- lymph node hyperplasia
- multifocal hepatic necrosis
- myeloid hyperplasia
- pallor
- postnatal lethality incomplete penetrance
- premature death
- reticulocytopenia
- spleen hyperplasia
- thymus cortex hypoplasia
- thymus hypoplasia
role in cell
- expression in
- apoptosis
- activation in
- cell death
- production in
- proliferation
- morphology
- quantity
- binding in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear speckles
- chromatin structures
- centromeres
- centromeric heterochromatin
- pericentric heterochromatin
- toroidal chromatin structures
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ikzf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- negative regulation of transcription, DNA-dependent
- mesoderm development
- lymphocyte differentiation
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein domain specific binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding