Bard1 Gene Summary [Mouse]
Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of protein export from nucleus; protein K6-linked ubiquitination; and regulation of apoptotic process. Located in nucleus. Is expressed in central nervous system; genitourinary system; limb; and spleen. Used to study breast cancer. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bard1 |
| Official Name | BRCA1 associated RING domain 1 [Source:MGI Symbol;Acc:MGI:1328361] |
| Ensembl ID | ENSMUSG00000026196 |
| Bio databases IDs | |
| Aliases | BRCA1 associated RING domain 1 |
| Synonyms | BRAD1, BRCA1 associated RING domain 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bard1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding activity, bridging
- enzyme
- Ankyrin repeat
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- BRCA1 C Terminus (BRCT) domain
- breast cancer carboxy-terminal domain
- ankyrin repeats
- zinc-RING finger domain
- BRCT
- nuclear export signal
- BRCA1-binding domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- BRCT domain, a BRCA1 C-terminus domain
- alpha helix
- nuclear localization sequence
- Ankyrin repeats (3 copies)
- protein binding
- RNA binding
- phosphorylation site
- ubiquitin-protein transferase activity
- protein homodimerization
- protein heterodimerization
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Bard1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- colorectal neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- neoplasia
role in cell
- apoptosis
- survival
- DNA damage response
- expression in
- proliferation
- accumulation in
- transmembrane potential
- growth
- cell death
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- mitochondrial fraction
- mid-section
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- Mitochondria
- midbody
- nuclear foci
- chromosome
- nucleoplasm
- nuclear speckles
- mitotic spindle
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bard1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of protein export from nucleus
- regulation of DNA repair
- negative regulation of cell cycle
- positive regulation of protein catabolic process
- response to DNA damage stimulus
- regulation of phosphorylation
- tissue homeostasis
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- cellular response to ionizing radiation
- regulation of DNA damage checkpoint
- reciprocal DNA recombination
- negative regulation of mRNA 3'-end processing
- regulation of cell cycle
- protein K6-linked ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear ubiquitin ligase complex
- ubiquitin ligase complex
- cytoplasm
- nuclear speck
- BRCA1-C complex
- BRCA1-A complex
- BRCA1-B complex
- BRCA1-BARD1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- RNA binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- metal ion binding
- kinase binding