Syngr1 Gene Summary [Mouse]
Involved in regulation of long-term neuronal synaptic plasticity and regulation of short-term neuronal synaptic plasticity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human SYNGR1 (synaptogyrin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syngr1 |
| Official Name | synaptogyrin 1 [Source:MGI Symbol;Acc:MGI:1328323] |
| Ensembl ID | ENSMUSG00000022415 |
| Bio databases IDs | |
| Aliases | synaptogyrin 1 |
| Synonyms | p29, synaptogyrin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syngr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- rheumatoid arthritis
- primary biliary cirrhosis
- squamous-cell carcinoma
- squamous cell cancer
- susceptibility to rheumatoid arthritis
regulates
- GH1
role in cell
- plasticity
- organization
- outgrowth
- paired-pulse facilitation
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- cellular membrane
- secretory granule membrane
- lysosome membrane
- synaptic vesicles
- synapse
- synaptic-like microvesicles
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syngr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- regulation of long-term neuronal synaptic plasticity
- synaptic vesicle membrane organization
- regulated secretory pathway
- regulation of short-term neuronal synaptic plasticity
Cellular Component
Where in the cell the gene product is active
- melanosome
- neuromuscular junction
- synaptic vesicle membrane
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding