Slc39a8 Gene Summary [Mouse]
Enables zinc:bicarbonate symporter activity. Involved in several processes, including bicarbonate transport; intracellular monoatomic cation homeostasis; and monoatomic cation transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a8 |
| Official Name | solute carrier family 39 (metal ion transporter), member 8 [Source:MGI Symbol;Acc:MGI:1914797] |
| Ensembl ID | ENSMUSG00000053897 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (metal ion transporter), member 8 |
| Synonyms | 4933419D20Rik, BIGM103, CDG2N, DKFZp564A132, LOC108350117, LOC64116, LZT-Hs6, PP3105, solute carrier family 39 member 8, solute carrier family 39 (metal ion transporter), member 8, ZIP8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZIP Zinc transporter
- solute:cation symporter
- zinc ion transporter
- bicarbonate transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc39a8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- inflammatory bowel disease
- epithelial cancer
- heart failure
- sleep apnea syndrome
- renal cell carcinoma
- renal cell cancer
- prostate cancer
- obesity
- androgenic alopecia
role in cell
- expression in
- production in
- downregulation in
- upregulation in
- cell death
- transmembrane potential
- number
- signaling in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
- apical membrane
- basolateral membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mercury ion transport
- transcription, DNA-dependent
- negative regulation of inflammatory response
- cellular zinc ion homeostasis
- protein N-linked glycosylation
- regulation of transcription, DNA-dependent
- plasma membrane selenite transport
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- cobalt ion transport
- arginine metabolic process
- regulation of membrane potential
- zinc ion transport
- manganese ion transmembrane transport
- cadmium ion transmembrane transport
- extracellular matrix organization
- zinc ion import
- zinc ion transmembrane transport
- cellular manganese ion homeostasis
- cellular cation homeostasis
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- organelle membrane
- basolateral plasma membrane
- lysosomal membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion transmembrane transporter activity