Ano6 Gene Summary [Mouse]
Enables monoatomic ion channel activity; phospholipid scramblase activity; and protein homodimerization activity. Involved in several processes, including bleb assembly; monoatomic ion transmembrane transport; and positive regulation of transport. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; calcium activated phospholipid scrambling; and dendritic cell chemotaxis. Located in plasma membrane. Is active in cholinergic synapse and synaptic membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; nervous system; sensory organ; and skeletal system. Human ortholog(s) of this gene implicated in Scott syndrome; ankylosing spondylitis; and inflammatory bowel disease. Orthologous to human ANO6 (anoctamin 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ano6 |
| Official Name | anoctamin 6 [Source:MGI Symbol;Acc:MGI:2145890] |
| Ensembl ID | ENSMUSG00000064210 |
| Bio databases IDs | |
| Aliases | anoctamin 6 |
| Synonyms | 2900059G15Rik, anoctamin 6, BDPLT7, Dkfzp313m0720, F730003B03Rik, SCTS, TMEM16F |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ano6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- Calcium-activated chloride channel
- phospholipid scramblase
- dimerization domain of Ca+-activated chloride-channel, anoctamin
- chloride channel
- intracellular calcium activated chloride channel
- protein homodimerization
- protein binding
- identical protein binding
- voltage-gated ion channel
- voltage-gated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ankylosing spondylitis
- non-insulin-dependent diabetes mellitus
- autosomal recessive nonsyndromic hydrocephalus type 2
- exhaustion
- Scott syndrome
- prostate cancer
- dementia
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
role in cell
- proliferation
- generation in
- apoptosis
- production in
- chemotaxis
- activation
- function
- volume
- exposure in
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- tertiary granule membrane
- specific granule membrane
- cytosol
- synaptic membrane
- synapse
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ano6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phagocytosis, engulfment
- bleb assembly
- purinergic nucleotide receptor signaling pathway
- positive regulation of monocyte chemotaxis
- ion transmembrane transport
- pore complex assembly
- blood coagulation
- chloride transport
- phosphatidylserine exposure on blood platelet
- activation of blood coagulation via clotting cascade
- negative regulation of cell volume
- positive regulation of apoptotic process
- phospholipid scrambling
- calcium ion transmembrane transport
- positive regulation of endothelial cell apoptotic process
- sodium ion transmembrane transport
- positive regulation of bone mineralization
- positive regulation of ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- extracellular vesicular exosome
- membrane
- cytosol
- plasma membrane
- tertiary granule membrane
- cell surface
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- protein binding
- intracellular calcium activated chloride channel activity
- metal ion binding
- protein dimerization activity
- voltage-gated ion channel activity
- chloride channel activity
- phospholipid scramblase activity
- voltage-gated chloride channel activity