Sh3bp1 Gene Summary [Mouse]
Enables GTPase activator activity and SH3 domain binding activity. Involved in positive regulation of GTPase activity and ruffle assembly. Located in bicellular tight junction. Orthologous to human SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3bp1 |
| Official Name | SH3-domain binding protein 1 [Source:MGI Symbol;Acc:MGI:104603] |
| Ensembl ID | ENSMUSG00000022436 |
| Bio databases IDs | |
| Aliases | SH3-domain binding protein 1 |
| Synonyms | 3BP-1, ARHGAP43, SH3-domain binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh3bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- semaphorin receptor binding
- GTPase activator
- BAR domain
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
- SH3-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- inhibition in
- growth
- apoptosis
- migration
- generation in
- morphology
- organization
- assembly
- ruffling
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- cytosol
- tight junctions
- cell membrane leading edge
- cell-cell adherens junctions
- lamellipodia
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh3bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rac protein signal transduction
- actin filament organization
- filopodium assembly
- positive regulation of GTPase activity
- regulation of blood vessel endothelial cell migration
- negative regulation of small GTPase mediated signal transduction
- regulation of actin cytoskeleton organization
- phagocytosis, engulfment
- regulation of actin filament depolymerization
- ruffle assembly
- regulation of small GTPase mediated signal transduction
- establishment of epithelial cell apical/basal polarity
- cell junction assembly
- cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- adherens junction
- tight junction
- cell leading edge
- cytosol
- phagocytic cup
- intracellular
- exocyst
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- SH3 domain binding
- semaphorin receptor binding