Pacsin2 Gene Summary [Mouse]
Enables cytoskeletal protein binding activity; lipid binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; cell projection morphogenesis; and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in caveola; cell-cell junction; and cytosol. Is active in adherens junction and glutamatergic synapse. Is expressed in several structures, including alimentary system; aorta; cerebral cortex ventricular layer; genitourinary system; and thymus. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pacsin2 |
| Official Name | protein kinase C and casein kinase substrate in neurons 2 [Source:MGI Symbol;Acc:MGI:1345153] |
| Ensembl ID | ENSMUSG00000016664 |
| Bio databases IDs | |
| Aliases | protein kinase C and casein kinase substrate in neurons 2 |
| Synonyms | protein kinase C and casein kinase substrate in neurons 2, SDP2, SDPII, SYNDAPIN2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pacsin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- lipid binding
- variable domain
- protein binding activity, bridging
- Fes/CIP4, and EFC/F-BAR homology domain
- coiled-coil domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
- binding protein
- cytoskeletal protein binding
- NPF motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- inflammatory bowel disease
- metabolic syndrome X
- peripheral arterial disease
- exercise intolerance
- early onset hypertension
role in cell
- proliferation
- activation in
- phosphorylation in
- expression in
- apoptosis
- migration
- binding in
- formation
- action potential
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cilia
- membrane surface
- cellular membrane
- Plasma Membrane
- centrosome
- intercellular junctions
- cytosol
- caveolae
- endosomal membrane
- nuclear speckles
- synapse
- perinuclear vesicles
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pacsin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
- negative regulation of endocytosis
- caveola assembly
- cytoskeleton organization
- protein localization in endosome
- caveolin-mediated endocytosis
- regulation of synaptic transmission
- regulation of endocytosis
- actin cytoskeleton organization
- cell projection morphogenesis
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- nuclear speck
- plasma membrane
- early endosome
- caveola
- cell-cell junction
- endosome
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- intracellular membrane-bounded organelle
- ruffle membrane
- cytosol
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cadherin binding
- phosphatidic acid binding
- phospholipid binding
- cytoskeletal protein binding