Arhgap44 Gene Summary [Mouse]
Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including negative regulation of Rac protein signal transduction; regulation of dendritic spine morphogenesis; and regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane. Located in dendritic spine. Is active in glutamatergic synapse. Is expressed in central nervous system; olfactory epithelium; respiratory system; and retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap44 |
| Official Name | Rho GTPase activating protein 44 [Source:MGI Symbol;Acc:MGI:2144423] |
| Ensembl ID | ENSMUSG00000033389 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 44 |
| Synonyms | 6330543G20, KIAA0672, NPC-A-10, RGD1305664, Rho GTPase activating protein 44, RICH-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- phospholipid binding
- enzyme binding
- GTPase activator
- BAR domain
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- cleft lip
- organismal death
- multiple system atrophy
- osteosarcoma
- osteosarcomagenesis
role in cell
- apoptosis
- binding in
- expression in
- binding
- migration
- invasion by
- proliferation
- quantity
- assembly
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- cytosol
- dendritic spines
- synapse
- cell membrane leading edge
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- regulation of actin cytoskeleton organization
- signal transduction
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- negative regulation of Rac protein signal transduction
- regulation of synaptic transmission
- negative regulation of filopodium assembly
- exocytosis
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- presynaptic active zone
- dendritic spine
- cytosol
- leading edge membrane
- recycling endosome
- intracellular
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- small GTPase binding
- phospholipid binding