Atp13a3 Gene Summary [Mouse]
Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type transmembrane transporter activity; and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be located in early endosome membrane and recycling endosome membrane. Predicted to be active in late endosome membrane. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp13a3 |
| Official Name | ATPase type 13A3 [Source:MGI Symbol;Acc:MGI:2685387] |
| Ensembl ID | ENSMUSG00000022533 |
| Bio databases IDs | |
| Aliases | ATPase type 13A3 |
| Synonyms | AFURS1, ATPase 13A3, ATPase type 13A3, AU022875, FLJ20986, Gm1745, Gm541, Gm542, PPH5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp13a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- Cation transporter/ATPase, N-terminus
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- heavy metal translocating P-type ATPase
- E1-E2 ATPase
- P-type ATPase of unknown pump specificity (type V)
- copper-(or silver)-translocating P-type ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- plasma-membrane calcium-translocating P-type ATPase
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Haloacid Dehalogenase-like Hydrolases
- transporter
- P5-type ATPase cation transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp13a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- putrescine transport
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- polyamine transmembrane transporter activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
- cation-transporting ATPase activity
- metal ion binding
- putrescine-importing ATPase activity