ATP13A3 Gene Summary [Human]
ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | ATP13A3 |
| Official Name | ATPase 13A3 [Source:HGNC Symbol;Acc:HGNC:24113] |
| Ensembl ID | ENSG00000133657 |
| Bio databases IDs | |
| Aliases | ATPase 13A3, ATPase family homolog up regulated in senescence cells |
| Synonyms | AFURS1, ATPase 13A3, ATPase type 13A3, AU022875, FLJ20986, Gm1745, Gm541, Gm542, PPH5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP13A3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- Cation transporter/ATPase, N-terminus
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- heavy metal translocating P-type ATPase
- E1-E2 ATPase
- P-type ATPase of unknown pump specificity (type V)
- copper-(or silver)-translocating P-type ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- plasma-membrane calcium-translocating P-type ATPase
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Haloacid Dehalogenase-like Hydrolases
- transporter
- P5-type ATPase cation transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP13A3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- putrescine transport
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- polyamine transmembrane transporter activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
- cation-transporting ATPase activity
- metal ion binding
- putrescine-importing ATPase activity