Septin12 Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be located in several cellular components, including midbody; perinuclear region of cytoplasm; and sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in testis. Human ortholog(s) of this gene implicated in spermatogenic failure 10. Orthologous to human SEPTIN12 (septin 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin12 |
| Official Name | septin 12 [Source:MGI Symbol;Acc:MGI:1918339] |
| Ensembl ID | ENSMUSG00000022542 |
| Bio databases IDs | |
| Aliases | septin 12 |
| Synonyms | 1700028G04Rik, 4933413B09Rik, SEPT12, SPGF10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Septin12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- GDP binding
- protein homodimerization
- protein binding
- identical protein binding
- phosphatidylinositol binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- annulus
- sperm annulus
- spindle apparatus
- perinuclear region
- Mitochondria
- midbody
- nuclear rim
- sperm head
- actin stress fibers
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Septin12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- cell differentiation
- protein localization
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- perinuclear region of cytoplasm
- cell division site
- cleavage furrow
- sperm annulus
- stress fiber
- spindle
- midbody
- septin complex
- septin ring
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- GTPase activity
- GDP binding
- phosphatidylinositol binding
- binding, bridging