Lynx1 Gene Summary [Mouse]
Enables acetylcholine receptor inhibitor activity and ion channel inhibitor activity. Acts upstream of or within cholinergic synaptic transmission. Located in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and respiratory system. Orthologous to several human genes including LYNX1 (Ly6/neurotoxin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lynx1 |
| Official Name | Ly6/neurotoxin 1 [Source:MGI Symbol;Acc:MGI:1345180] |
| Ensembl ID | ENSMUSG00000022594 |
| Bio databases IDs | |
| Aliases | Ly6/neurotoxin 1 |
| Synonyms | Ly6/neurotoxin 1, LY6/NEUROTOXIN-LIKE protein 1, SLURP-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lynx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel inhibitor
- acetylcholine receptor inhibitor
- protein binding
- receptor binding
- TFP
- acetylcholine receptor regulator
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- colon adenocarcinoma
- colon epithelial cancer
regulates
- NACHR
- Ca2+
- nicotinic acetylcholine receptor
role in cell
- activation
- degeneration
- formation
- synaptic transmission
- excitotoxicity
- desensitization in
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic region
- cellular membrane
- dendrite initial segments
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lynx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
Cellular Component
Where in the cell the gene product is active
- dendrite
- endoplasmic reticulum
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor regulator activity
- acetylcholine receptor binding
- acetylcholine receptor inhibitor activity
- ion channel inhibitor activity