Chrna7 Gene Summary [Mouse]
Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Is active in cholinergic synapse; postsynaptic specialization membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to several human genes including CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrna7 |
| Official Name | cholinergic receptor, nicotinic, alpha polypeptide 7 [Source:MGI Symbol;Acc:MGI:99779] |
| Ensembl ID | ENSMUSG00000030525 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, nicotinic, alpha polypeptide 7 |
| Synonyms | Acra7, alpha7, cholinergic receptor, nicotinic, alpha polypeptide 7, cholinergic receptor, nicotinic, α polypeptide 7, nAchR, nAChR alpha7 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrna7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- excitatory extracellular ligand-gated ion channel
- protein kinase binding
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- beta-amyloid binding
- chloride channel regulator
- ion channel
- acetylcholine receptor
- ATPase binding
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- adenylate cyclase binding
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- protein homodimerization
- acetylcholine binding
- cation channel
- transmembrane receptor
- toxin binding
Pathways
Biological processes and signaling networks where the Chrna7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperactive behavior
- asthenozoospermia
- glomerulosclerosis
- pharmacologically induced seizure
role in cell
- cell death
- transmembrane potential
- activation
- turnover
- hyperexcitation
- motility
- infiltration by
- formation
- cellular infiltration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- presynaptic regions
- cell surface
- cellular membrane
- plasma membrane extracellular face
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- neuromuscular junctions
- axonal membrane
- growth cone
- synapse
- membrane rafts
- perikaryon
- axons
- dendrites
- dendritic shafts