Trim55 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Acts upstream of or within with a positive effect on diapedesis and leukocyte migration involved in inflammatory response. Acts upstream of or within with a negative effect on macrophage migration. Acts upstream of or within defense response to virus; inflammatory response; and macrophage activation. Predicted to be active in cytoplasm. Is expressed in cardiac muscle tissue; heart; heart left ventricle; and left atrium. Orthologous to human TRIM55 (tripartite motif containing 55). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim55 |
| Official Name | tripartite motif-containing 55 [Source:MGI Symbol;Acc:MGI:3036269] |
| Ensembl ID | ENSMUSG00000060913 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 55 |
| Synonyms | D830041C10Rik, LOC101060153, MURF-2, RNF29, tripartite motif-containing 55 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim55 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- protein binding activity, bridging
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cardiac hypertrophy
- lung adenocarcinoma
- lung adenocarcinoma formation
- major depression
- colorectal cancer
- weight gain
- bleeding
- pulmonary edema
- mixed connective tissue disease
regulated by
- decitabine
- beta-estradiol
- medroxyprogesterone acetate
- GDF2
- SUPT16H
role in cell
- expression in
- invasion by
- degradation in
- replication in
- migration
- downregulation in
- survival
- size
- growth
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim55 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukocyte migration involved in inflammatory response
- protein K48-linked ubiquitination
- signal transduction
- diapedesis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- protein binding, bridging