Tmem106b Gene Summary [Mouse]
Enables ATPase binding activity. Acts upstream of or within several processes, including lysosomal lumen acidification; lysosomal protein catabolic process; and positive regulation of dendrite development. Located in lysosome. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 16. Orthologous to human TMEM106B (transmembrane protein 106B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem106b |
| Official Name | transmembrane protein 106B [Source:MGI Symbol;Acc:MGI:1919150] |
| Ensembl ID | ENSMUSG00000029571 |
| Bio databases IDs | |
| Aliases | transmembrane protein 106B |
| Synonyms | 2310036D22Rik, 5830455K21Rik, 6430519M21Rik, HLD16, LRRGT00101, transmembrane protein 106B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem106b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- Protein of unknown function (DUF1356)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- metabolic syndrome X
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- astrocytosis
- coronary artery disease
- hypomyelinating leukodystrophy type 16
- major depression
- microgliosis
- insomnia
role in cell
- proliferation
- cell viability
- molecular cleavage in
- cell death
- number
- activation
- loss
- morphogenesis
- organization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endosomes
- lysosome
- lysosome membrane
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem106b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- lysosome organization
- neuron homeostasis
- lysosomal transport
- lysosomal lumen acidification
- positive regulation of dendrite development
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- endosome
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase binding