Timp2 Gene Summary [Mouse]
Enables enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Timp2 |
| Official Name | tissue inhibitor of metalloproteinase 2 [Source:MGI Symbol;Acc:MGI:98753] |
| Ensembl ID | ENSMUSG00000017466 |
| Bio databases IDs | |
| Aliases | tissue inhibitor of metalloproteinase 2 |
| Synonyms | CSC-21K, D11Bwg1104e, DDC8, TIMP metallopeptidase inhibitor 2, tissue inhibitor of metalloproteinase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Timp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- AB loop
- protease binding
- zinc ion binding
- CD loop
- protease inhibitor
- integrin binding
- protein binding
- enzyme activator activity
- loop domain
- metalloendopeptidase inhibitor
- Tissue inhibitor of metalloproteinase
Pathways
Biological processes and signaling networks where the Timp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- diabetes mellitus
- obesity
- organismal death
- psoriasis
- neoplasia
- preeclampsia
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- outgrowth
- growth
- activation in
- expression in
- apoptosis
- phosphorylation in
- survival
- invasion
- activity
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- cell surface
- cell borders
- apical compartment
- organelle lumens
- cellular membrane
- Plasma Membrane
- growth cone
- cytoplasmic vesicles
- extracellular matrix
- brush border
- perikaryon
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Timp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of membrane protein ectodomain proteolysis
- negative regulation of endopeptidase activity
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- specific granule lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity
- zinc ion binding
- protein binding
- protease binding
- metalloendopeptidase inhibitor activity