Sik3 Gene Summary [Mouse]
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Acts upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Located in cytoplasm. Is expressed in Meckel's cartilage and vibrissa. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sik3 |
| Official Name | SIK family kinase 3 [Source:MGI Symbol;Acc:MGI:2446296] |
| Ensembl ID | ENSMUSG00000034135 |
| Bio databases IDs | |
| Aliases | SIK family kinase 3 |
| Synonyms | 5730525O22Rik, 9030204A07RIK, KIAA0999, L19, LOC689939, mKIAA0999, QSK, SEMDK, SIK family kinase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sik3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Sik3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- metabolic syndrome X
- hypersomnia
- scoliosis
- Krakow type spondyloepimetaphyseal dysplasia
- cholestasis
- diverticular disease
- rickets
- nonalcoholic fatty liver disease
- sleep need disorder
phenotypes
- abnormal bone structure
- abnormal coat/hair pigmentation
- abnormal cornea morphology
- abnormal cranium morphology
- abnormal femur morphology
- abnormal fibula morphology
- abnormal humerus morphology
- abnormal joint morphology
- abnormal pelvic girdle bone morphology
- abnormal radius morphology
- abnormal retina morphology
- abnormal rib morphology
- abnormal spine curvature
- abnormal tail morphology
- abnormal thoracic cage shape
- abnormal tibia morphology
- abnormal ulna morphology
- abnormal vertebrae morphology
- abnormal zygomatic bone morphology
- decreased CD4-positive NK T cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD5-positive gamma-delta T cell number
- decreased KLRG1-positive NK cell number
- decreased KLRG1-positive T-helper cell number
- decreased Ly6C-positive mature NK cell number
- decreased NK T cell number
- decreased NK cell number
- decreased T cell number
- decreased T-helper cell number
- decreased alpha-beta T cell number
- decreased blood urea nitrogen level
- decreased circulating HDL cholesterol level
- decreased circulating calcium level
- decreased circulating cholesterol level
- decreased circulating free fatty acid level
- decreased circulating fructosamine level
- decreased circulating glucose level
- decreased circulating glycerol level
- decreased circulating insulin level
- decreased circulating potassium level
- decreased circulating triglyceride level
- decreased early germinal center B cell number
- decreased effector memory T-helper cell number
- decreased erythrocyte cell number
- decreased gamma-delta T cell number
- decreased germinal center B cell number
- decreased memory-marker CD4-negative NK T cell number
- decreased memory-marker CD4-positive NK T cell number
- decreased regulatory T cell number
- decreased total body fat amount
- female infertility
- improved glucose tolerance
- increased CD4-negative NK T cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD8-positive alpha-beta T cell number
- increased CD8-positive naive alpha-beta T cell number
- increased KLRG1+ CD8 alpha beta T cell number
- increased KLRG1-positive CD4-negative NK T cell number
- increased KLRG1-positive CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased KLRG1-positive T-helper cell number
- increased Ly6C-positive NK T cell number
- increased NK cell number
- increased bone mineral content
- increased circulating alkaline phosphatase level
- increased circulating bilirubin level
- increased circulating sodium level
- increased effector memory T-helper cell number
- increased eosinophil cell number
- increased follicular B cell number
- increased granulocyte number
- increased heart weight
- increased lean body mass
- increased mean corpuscular hemoglobin
- increased memory-marker NK cell number
- increased memory-marker gamma-delta T cell number
- increased plasmacytoid dendritic cell number
- increased red blood cell distribution width
- kyphosis
- obsolete decreased CD4-positive alpha beta T cell number
- thrombocytopenia
- abnormal adipose tissue amount
- abnormal bile color
- abnormal bile composition
- abnormal blood urea nitrogen level
- abnormal bone mineralization
- abnormal brain wave pattern
- abnormal cartilage morphology
- abnormal cholesterol level
- abnormal circadian sleep/wake cycle
- abnormal circulating alkaline phosphatase level
- abnormal circulating free fatty acids level
- abnormal circulating glucose level
- abnormal circulating hormone level
- abnormal circulating insulin level
- abnormal circulating protein level
- abnormal eating behavior
- abnormal energy homeostasis
- abnormal fat cell differentiation
- abnormal gallbladder epithelium morphology
- abnormal gallbladder morphology
- abnormal glucose homeostasis
- abnormal glucose tolerance
- abnormal hepatocyte morphology
- abnormal homeostasis
- abnormal lean body mass
- abnormal limb long bone morphology
- abnormal lipid homeostasis
- abnormal liver morphology
- abnormal mean corpuscular hemoglobin
- abnormal non-rapid eye movement sleep pattern
- abnormal paradoxical sleep pattern
- abnormal parietal bone morphology
- abnormal retinol level
- abnormal sleep pattern
- abnormal vertebral column morphology
- cholestasis
- decreased body size
- decreased body weight
- decreased brown adipose tissue amount
- decreased chondrocyte number
- decreased circulating VLDL triglyceride level
- decreased circulating alanine transaminase level
- decreased circulating leptin level
- decreased fat cell size
- decreased gonadal fat pad weight
- decreased kidney weight
- decreased length of long bones
- decreased liver cholesterol level
- decreased liver triglyceride level
- decreased liver weight
- decreased mesenteric fat pad weight
- decreased pancreas weight
- decreased renal fat pad weight
- decreased subcutaneous adipose tissue amount
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased width of hypertrophic chondrocyte zone
- delayed cranial suture closure
- delayed intramembranous bone ossification
- enlarged gallbladder
- increased adiponectin level
- increased bile salt level
- increased circulating alanine transaminase level
- increased circulating triglyceride level
- increased core body temperature
- increased liver cholesterol level
- increased long bone epiphyseal plate size
- increased oxygen consumption
- increased respiratory quotient
- intrahepatic cholestasis
- large fontanelles
- neonatal lethality incomplete penetrance
- rachitic rosary
- rickets
- scoliosis
- short ribs
- short sternum
role in cell
- production in
- expression in
- phosphorylation in
- differentiation
- size
- number
- colony formation by
- binding in
- expansion
- endochondral ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sik3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule cytoskeleton organization
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity