Sik3 Gene Summary [Mouse]
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Acts upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Located in cytoplasm. Is expressed in Meckel's cartilage and vibrissa. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sik3 |
| Official Name | SIK family kinase 3 [Source:MGI Symbol;Acc:MGI:2446296] |
| Ensembl ID | ENSMUSG00000034135 |
| Bio databases IDs | |
| Aliases | SIK family kinase 3 |
| Synonyms | 5730525O22Rik, 9030204A07RIK, KIAA0999, L19, LOC689939, mKIAA0999, QSK, SEMDK, SIK family kinase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sik3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Sik3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- metabolic syndrome X
- hypersomnia
- scoliosis
- Krakow type spondyloepimetaphyseal dysplasia
- cholestasis
- diverticular disease
- rickets
- nonalcoholic fatty liver disease
- sleep need disorder
role in cell
- production in
- expression in
- phosphorylation in
- differentiation
- size
- number
- colony formation by
- binding in
- expansion
- endochondral ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sik3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule cytoskeleton organization
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity