Rpl5 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in several processes, including protein stabilization; regulation of protein metabolic process; and ribosome biogenesis. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including central nervous system; gonad; intestine; sensory organ; and spleen. Used to study Diamond-Blackfan anemia 6. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl5 |
| Official Name | ribosomal protein L5 [Source:MGI Symbol;Acc:MGI:102854] |
| Ensembl ID | ENSMUSG00000058558 |
| Bio databases IDs | |
| Aliases | ribosomal protein L5 |
| Synonyms | L5, MSTP030, PPP1R135, ribosomal L5, Ribosomal protein l1a, ribosomal protein L5, Ska23, Ska<m23Jus>, Skax23, U21RNA, uL18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- mRNA binding
- 5S rRNA binding
- enzyme inhibitor activity
- Ribosomal L18 C-terminal region
- protein binding
- enzyme regulator activity
- RNA binding
- mRNA 3' UTR binding
- structural constituent of ribosome
- mRNA 5' UTR binding
- Ribosomal large subunit proteins 60S L5, and 50S L18
- Ribosomal_L18_L5e
Pathways
Biological processes and signaling networks where the Rpl5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- glioblastoma
- glioblastoma cancer
- Diamond-Blackfan anemia
- diamond-blackfan anemia type 6
- lung adenocarcinoma
- lung adenocarcinoma formation
- hereditary disorder
- uterine corpus endometrioid carcinoma
- epithelial uterine cancer
role in cell
- expression in
- cell death
- activation in
- binding in
- G1/S phase transition
- translation in
- co-localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- Endoplasmic Reticulum
- polysomes
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- synapse
- postsynaptic density
- free polysome fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- positive regulation of gene expression
- cytoplasmic translation
- ribosomal large subunit biogenesis
- rRNA processing
- ribosomal large subunit assembly
- protein stabilization
- negative regulation of protein neddylation
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- translation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- endoplasmic reticulum
- cytosolic large ribosomal subunit
- nucleolus
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- RNA binding
- protein binding
- structural constituent of ribosome
- mRNA 5'-UTR binding
- 5S rRNA binding
- mRNA 3'-UTR binding