Rrs1 Gene Summary [Mouse]
Predicted to enable 5S rRNA binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in endoplasmic reticulum and nucleolus. Is expressed in several structures, including adrenal gland; head mesenchyme; jaw; nasal capsule; and submandibular gland primordium. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrs1 |
| Official Name | ribosome biogenesis regulator 1 [Source:MGI Symbol;Acc:MGI:1929721] |
| Ensembl ID | ENSMUSG00000061024 |
| Bio databases IDs | |
| Aliases | ribosome biogenesis regulator 1 |
| Synonyms | 5730466A07Rik, AA415037, D1Ertd701e, KIAA0112, Regulator for ribosome resistance homolog, ribosome biogenesis regulator 1, ribosome biogenesis regulator 1 homolog, Rrr |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rrs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosome biogenesis regulatory protein (RRS1)
- 5S rRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
regulates
- ERK1/2
- BCL2
- ABCB1
- ribosomal large subunit
- Ribosomal Subunit 60s
role in cell
- cell viability
- expression in
- proliferation
- phosphorylation in
- apoptosis
- G1 phase
- differentiation
- cisplatin sensitivity
- processing in
- misalignment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Endoplasmic Reticulum
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rrs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal large subunit biogenesis
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal large subunit assembly
- mitotic metaphase plate congression
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- nucleolus
- condensed nuclear chromosome
- nucleoplasm
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- 5S rRNA binding