Umps Gene Summary [Mouse]
Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb bud; metanephros; pancreas; and surface ectoderm. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Umps |
| Official Name | uridine monophosphate synthetase [Source:MGI Symbol;Acc:MGI:1298388] |
| Ensembl ID | ENSMUSG00000022814 |
| Bio databases IDs | |
| Aliases | uridine monophosphate synthetase |
| Synonyms | 1700095D23RIK, BB164745, OPRT, Orotidylic acid (OMP) decarboxylase, uridine monophosphate synthetase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Umps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TIM-like beta/alpha barrel domains
- orotate phosphoribosyltransferase
- Phosphoribosyl transferase domain
- orotidine-5'-phosphate decarboxylase
- Phosphoribosyl transferase (PRT)-type I domain
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- advanced esophageal cancer
- hereditary orotic aciduria
- extrahepatic cholangiocarcinoma
- gastroesophageal junction adenocarcinoma
- gastric cancer
- metastatic colorectal cancer
- esophagogastric junction cancer
- locally advanced gastric adenocarcinoma
- carcinoma of ampulla of Vater
regulates
- UMP
- uridine diphosphate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Umps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 'de novo' pyrimidine base biosynthetic process
- UMP biosynthetic process
- female pregnancy
- lactation
- cellular response to xenobiotic stimulus
- 'de novo' UMP biosynthetic process
- pyrimidine base biosynthetic process
- UDP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- orotidine-5'-phosphate decarboxylase activity
- orotate phosphoribosyltransferase activity