Fam3b Gene Summary [Mouse]
Predicted to enable cytokine activity. Involved in insulin secretion. Predicted to be located in nuclear envelope lumen. Predicted to be active in extracellular space. Is expressed in several structures, including branchial arch; heart; stomach; surface ectoderm; and testis. Orthologous to human FAM3B (FAM3 metabolism regulating signaling molecule B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam3b |
| Official Name | family with sequence similarity 3, member B [Source:MGI Symbol;Acc:MGI:1270150] |
| Ensembl ID | ENSMUSG00000022938 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 3, member B |
| Synonyms | 2-21, 9030624C24Rik, C21orf11, C21orf76, D16Jhu19e, FAM3 metabolism regulating signaling molecule B, ORF9, PANDER, PRED44, RGD1311662 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interleukin-like EMT inducer
- protein binding
- cytokine
- Domains similar to the Pancreatic-derived factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
- nonsyndromic orofacial cleft
- antineutrophil cytoplasmic antibody-associated vasculitis
regulated by
- D-glucose
- insulin
- INSR
- Go 6976
- H89
- L-arginine
- N-acetyl-L-cysteine
- pyrrolidine dithiocarbamate
- PI3K (complex)
- PD98059
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- exocytic vesicle
- cell periphery
- Endoplasmic Reticulum
- granules
- perinuclear space
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion
- signal transduction
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- carbohydrate binding
- cytokine activity