Dcn Gene Summary [Mouse]
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Dcn |
| Official Name | decorin [Source:MGI Symbol;Acc:MGI:94872] |
| Ensembl ID | ENSMUSG00000019929 |
| Bio databases IDs | |
| Aliases | decorin |
| Synonyms | Bone proteoglycan II, CSCD, DC, Decorin, DSPG2, PG40, PGII, PGS2, SLRR1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dcn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- core
- extracellular matrix structural constituent conferring compression resistance
- extracellular matrix binding
- Leucine rich repeat
- collagen binding
- Leucine rich repeat N-terminal domain
- protein binding
- Leucine Rich repeats (2 copies)
- glycosaminoglycan binding
Pathways
Biological processes and signaling networks where the Dcn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- tumorigenesis
- cancer
- fibrosis
- epithelial cancer
- hepatocellular carcinoma
- tubulo-interstitial fibrosis
- congenital stromal corneal dystrophy
- endometrial adenocarcinoma
role in cell
- apoptosis
- proliferation
- expression in
- migration
- activation in
- growth
- binding in
- invasion by
- number
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- cell surface
- lysosomal compartment
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dcn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- positive regulation of macroautophagy
- negative regulation of vascular endothelial growth factor signaling pathway
- negative regulation of angiogenesis
- positive regulation of mitochondrial depolarization
- positive regulation of mitochondrial fission
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of endothelial cell migration
- positive regulation of protein kinase B signaling cascade
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- lysosomal lumen
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- RNA binding
- protein binding
- glycosaminoglycan binding
- extracellular matrix structural constituent conferring compression resistance