Itpa Gene Summary [Mouse]
Enables dITP diphosphatase activity. Acts upstream of or within ITP catabolic process and chromosome organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); developmental and epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itpa |
| Official Name | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) [Source:MGI Symbol;Acc:MGI:96622] |
| Ensembl ID | ENSMUSG00000074797 |
| Bio databases IDs | |
| Aliases | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) |
| Synonyms | 2010016I08Rik, C20orf37, DEE35, dJ794I6.3, HLC14-06-P, inosine triphosphatase, inosine triphosphatase (nucleoside triphosphate pyrophosphatase), Itp, ITPase, My049, NTPase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itpa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ham1 family
- nucleoside-triphosphate diphosphatase
- enzyme
- identical protein binding
- Maf_Ham1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic hepatitis C
- ataxia
- early infantile epileptic encephalopathy type 35
- thrombocytopenia
- inosine triphosphatase deficiency
- anemia
- hypodontia
- hypoplasia
- growth failure
- hereditary disorder
regulates
- ITP
- phosphate
- 6-mercaptopurine
- 6-thioguanylic acid
- XTP
role in cell
- number
- organization
- abnormal morphology
- metabolism in
- function
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itpa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ITP catabolic process
- chromosome organization
- nucleoside triphosphate catabolic process
- deoxyribonucleoside triphosphate catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- XTP diphosphatase activity
- dITP diphosphatase activity
- identical protein binding
- metal ion binding
- ITP diphosphatase activity
- nucleoside-triphosphate diphosphatase activity