Gle1 Gene Summary [Mouse]
Predicted to enable several functions, including identical protein binding activity; inositol hexakisphosphate binding activity; and translation initiation factor binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in cytosol; microtubule organizing center; and nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gle1 |
| Official Name | GLE1 RNA export mediator (yeast) [Source:MGI Symbol;Acc:MGI:1921662] |
| Ensembl ID | ENSMUSG00000019715 |
| Bio databases IDs | |
| Aliases | GLE1 RNA export mediator (yeast) |
| Synonyms | 4933405K21Rik, CAAHC, CAAHD, GLE1L, GLE1 RNA export mediator, hGLE1, LCCS, LCCS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gle1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- shuttling domain
- GLE1-like protein
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Gle1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- hypertension
- hereditary disorder
- Lethal congenital contractural syndrome Finnish type
- Lethal arthrogryposis with anterior horn cell disease
- GLE1-related disorder
- amyotrophic lateral sclerosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- centriole
- cytosol
- nuclear pores
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gle1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nucleocytoplasmic transport
- protein transport
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- centrosome
- extracellular space
- cilium basal body
- cytoplasm
- centriole
- membrane
- cytosol
- nucleolus
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- inositol hexakisphosphate binding
- phospholipid binding
- translation initiation factor binding