Calcoco1 Gene Summary [Mouse]
Enables chromatin binding activity and transcription coactivator activity. Involved in nuclear receptor-mediated steroid hormone signaling pathway and positive regulation of transcription by RNA polymerase II. Located in chromatin. Is expressed in several structures, including cerebral cortex; choroid plexus; and thymus primordium. Orthologous to human CALCOCO1 (calcium binding and coiled-coil domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calcoco1 |
| Official Name | calcium binding and coiled coil domain 1 [Source:MGI Symbol;Acc:MGI:1914738] |
| Ensembl ID | ENSMUSG00000023055 |
| Bio databases IDs | |
| Aliases | calcium binding and coiled coil domain 1 |
| Synonyms | 1810009B06RIK, calcium binding and coiled-coil domain 1, calphoglin, Cocoa, Gcap11, LOC100912282, mKIAA1536, NCoCoA, PP13275 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Calcoco1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Mitotic checkpoint protein
- activation domain
- transcription regulator
- Autophagy protein 16 (ATG16)
- SKICH domain
- transcription co-activator
- nucleic acid binding
- beta-catenin binding
- transcription cofactor
- coiled-coil domain
- leucine zipper domain
- chromatin binding
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Golgin subfamily A member 5
- sequence-specific DNA binding
- Laminin Domain I
- Fez1
- double-stranded DNA binding
- Zn-C2H2_CALCOCO1_TAX1BP1_like
- Autophagy receptor zinc finger-C2H2 domain
- Septation ring formation regulator, EzrA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Calcoco1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular steroid hormone receptor signaling pathway
- signal transduction
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- ligand-dependent nuclear receptor transcription coactivator activity
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- beta-catenin binding
- chromatin binding