Ptprr Gene Summary [Mouse]
Enables protein kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be active in cell junction; cytosol; and plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; and retina nuclear layer. Orthologous to human PTPRR (protein tyrosine phosphatase receptor type R). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprr |
| Official Name | protein tyrosine phosphatase, receptor type, R [Source:MGI Symbol;Acc:MGI:109559] |
| Ensembl ID | ENSMUSG00000020151 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, R |
| Synonyms | EC-PTP, Gmcp1, mPTP213, PC12-PTP1, PCPTP1, protein tyrosine phosphatase receptor type R, protein tyrosine phosphatase, receptor type, R, PTPBR7, PTPRQ, PTP-SL, R-PTP-R, RPTPRR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- protein binding
- PTP_DSP_cys
- phosphatase domain
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- cytoplasmic domain
- transmembrane receptor protein tyrosine phosphatase
- phosphatase
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Ptprr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- uterine leiomyoma
- endometriosis
- osteonecrosis
- refractive error
- gait disturbance
- leiomyomatosis
- COVID-19
- ovarian cancer
- organismal death
role in cell
- expression in
- cell death
- proliferation
- phosphorylation in
- migration by
- signaling in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- signal transduction
- negative regulation of ERK1 and ERK2 cascade
- protein dephosphorylation
- negative regulation of epithelial cell migration
- ERBB2 signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- cytosol
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein tyrosine phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity