Msrb2 Gene Summary [Mouse]
Enables actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Involved in actin filament polymerization and protein repair. Located in mitochondrion. Is expressed in several structures, including brown fat; heart; inner ear; skeletal muscle; and testis. Orthologous to human MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msrb2 |
| Official Name | methionine sulfoxide reductase B2 [Source:MGI Symbol;Acc:MGI:1923717] |
| Ensembl ID | ENSMUSG00000023094 |
| Bio databases IDs | |
| Aliases | methionine sulfoxide reductase B2 |
| Synonyms | 2310050L06Rik, CBS-1, CGI-131, methionine sulfoxide reductase B2, methionine sulphoxide reductase B2, Mrsb, MSRB, PILB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msrb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- actin binding
- sulfur group:disulfide oxidoreductase
- enzyme
- SelR domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- severe acute respiratory syndrome
- strictly segmental vitiligo
- bipolar disorder
regulates
- reactive oxygen species
- PARP1
role in cell
- production in
- apoptosis
- oxidation in
- transmembrane potential
- molecular cleavage in
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msrb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein repair
- response to oxidative stress
- actin filament polymerization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- actin binding
- L-methionine-(R)-S-oxide reductase activity
- peptide-methionine (R)-S-oxide reductase activity