Cit

Enables protein serine/threonine kinase activity. Involved in generation of neurons and mitotic cell cycle. Acts upstream of or within several processes, including dendrite development; metaphase/anaphase transition of mitotic cell cycle; and negative regulation of dendrite morphogenesis. Located in actin cytoskeleton; ruffle; and vacuole. Is expressed in several structures, including central nervous system; hemolymphoid system gland; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cit often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cit gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cit gene, providing context for its role in the cell.