Ndrg1 Gene Summary [Mouse]
Predicted to enable cadherin binding activity; small GTPase binding activity; and tubulin binding activity. Involved in negative regulation of cell population proliferation and peripheral nervous system myelin maintenance. Acts upstream of or within mast cell activation. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Charcot-Marie-Tooth disease type 4D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndrg1 |
| Official Name | N-myc downstream regulated gene 1 [Source:MGI Symbol;Acc:MGI:1341799] |
| Ensembl ID | ENSMUSG00000005125 |
| Bio databases IDs | |
| Aliases | N-myc downstream regulated gene 1 |
| Synonyms | CAP43, CMT4D, DRG-1, GC4, HMSNL, NDR1, NDRL, NMSL, N-myc Downstream Regulated 1, N-myc downstream regulated gene 1, N-myc downstream regulatory protein 1, PROXY1, RIT42, RTP, TARG1, TDD5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndrg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- gamma-tubulin binding
- microtubule binding
- protein serine/threonine kinase
- alpha/beta hydrolases
- nickel ion binding
- enzyme binding
- Ndr family
- cadherin binding
- protein binding
Pathways
Biological processes and signaling networks where the Ndrg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Charcot-Marie-Tooth disease type 4
- hereditary disorder
- renal clear cell adenocarcinoma
- Charcot-Marie-Tooth disease type 4D
- metastasis
- renal clear cell cancer
- uterine leiomyoma
- leiomyomatosis
- colorectal cancer
role in cell
- survival
- apoptosis
- phosphorylation in
- G2/M phase
- expression in
- proliferation
- invasion by
- activation in
- migration
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- myelin enriched fraction
- soluble fraction
- insoluble fractions
- microtubule cytoskeleton
- Cajal band
- Cytoplasm
- perinuclear region
- Plasma Membrane
- centrosome
- Golgi Apparatus
- microtubules
- cytosol
- endosomal membrane
- myelin sheath outer loop
- synaptic vesicles
- growth cone
- myelin sheath inner loop
- Schmidt-Lanterman incisures
- rough endoplasmatic reticulum
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndrg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- DNA damage response, signal transduction by p53 class mediator
- response to metal ion
- peripheral nervous system myelin maintenance
- mast cell activation
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- adherens junction
- microtubule cytoskeleton
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- cytosol
- recycling endosome membrane
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- small GTPase binding
- gamma-tubulin binding
- microtubule binding