Zdhhc17 Gene Summary [Mouse]
Enables palmitoyltransferase activity and signaling receptor binding activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of modification of synapse structure, modulating synaptic transmission; and regulation of signal transduction. Located in Golgi apparatus. Is active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynaptic Golgi apparatus. Is expressed in several structures, including early conceptus; heart; and oocyte. Used to study Huntington's disease. Orthologous to human ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc17 |
| Official Name | zinc finger, DHHC domain containing 17 [Source:MGI Symbol;Acc:MGI:2445110] |
| Ensembl ID | ENSMUSG00000035798 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 17 |
| Synonyms | A230053P19Rik, BB187739, D130071N24Rik, DHHC-17, HIP14, HIP3, HSPC294, HYPH, zD17, zinc finger, DHHC domain containing 17, zinc finger DHHC-type palmitoyltransferase 17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- DHHC motif
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- DHHC palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- enzyme
- protein binding
- receptor binding
- identical protein binding
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Zdhhc17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- leiomyomatosis
- Kawasaki disease
- behavioral deficit
- uterine leiomyoma
role in cell
- binding in
- phosphorylation in
- growth
- activation in
- binding
- cell death
- formation
- colony formation
- development
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- dendritic spine neck
- synapse
- recycling endosomes
- cytoplasmic vesicles
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ERK1 and ERK2 cascade
- regulation of nerve growth factor receptor signaling pathway
- axonogenesis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of programmed cell death
- protein palmitoylation
- lipoprotein transport
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- intracellular membrane-bounded organelle
- Golgi-associated vesicle membrane
- Golgi apparatus
- Golgi membrane
- cell projection
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein-cysteine S-palmitoleyltransferase activity
- protein-cysteine S-myristoyltransferase activity
- protein binding
- palmitoyltransferase activity
- receptor binding