Grm2 Gene Summary [Mouse]
Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within gene expression; intracellular glutamate homeostasis; and long-term synaptic depression. Located in neuron projection. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in brain; cerebellum internal granule cell layer; and telencephalon. Orthologous to human GRM2 (glutamate metabotropic receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grm2 |
| Official Name | glutamate receptor, metabotropic 2 [Source:MGI Symbol;Acc:MGI:1351339] |
| Ensembl ID | ENSMUSG00000023192 |
| Bio databases IDs | |
| Aliases | glutamate receptor, metabotropic 2 |
| Synonyms | 4930441L02RIK, GLUR2, glutamate metabotropic receptor 2, glutamate receptor, metabotropic 2, GPRC1B, Metabotropic glutamate receptor 2, MGLU2, MGLUR2, mGluR7, Mglur group 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Receptor family ligand binding region
- G beta gamma protein binding domain
- group II metabotropic glutamate receptor
- 7 transmembrane sweet-taste receptor of 3 GCPR
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- calcium channel regulator
- glutamate receptor
- NSF binding domain
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- cytosolic tail domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Grm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Glutamate Receptor Signaling
- Gαi Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Phagosome Formation
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- Huntington disease
- depressive disorder
- motor dysfunction or movement disorder
- early onset hypertension
- infection by vesicular stomatitis virus
regulates
- Ca2+
- cyclic AMP
- PKA
- N-type calcium channel
- G alpha-Q
- L-glutamic acid
- dopamine
- ADCY
- GNA15
- L-type calcium channel
role in cell
- apoptosis
- hyperpolarization
- depolarization
- long term synaptic depression
- excitotoxicity
- response by
- activity
- translation in
- action potential in
- neuroprotection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- neurites
- synapse
- axons
- dendrites
- axon terminals
- presynaptic terminals
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dopamine secretion
- regulation of glutamate secretion
- negative regulation of adenylate cyclase activity
- glutamate secretion
- behavioral response to nicotine
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- response to cocaine
- synaptic transmission
- G-protein coupled glutamate receptor signaling pathway
- gene expression
- long term synaptic depression
- regulation of response to drug
- regulation of synaptic transmission, glutamatergic
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- group II metabotropic glutamate receptor activity
- scaffold protein binding
- G-protein coupled receptor activity
- protein binding
- glutamate receptor activity
- calcium channel regulator activity