Grm7 Gene Summary [Mouse]
Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in presynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Used to study Werdnig-Hoffmann disease. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Grm7 |
| Official Name | glutamate receptor, metabotropic 7 [Source:MGI Symbol;Acc:MGI:1351344] |
| Ensembl ID | ENSMUSG00000056755 |
| Bio databases IDs | |
| Aliases | glutamate receptor, metabotropic 7 |
| Synonyms | 6330570A01RIK, C030018L03, E130018M02Rik, GLUR7, glutamate metabotropic receptor 7, glutamate receptor, metabotropic 7, Gpr1g, GPRC1G, Metabotropic glutamate receptor 7, MGLU7, MGLUR7, NEDSHBA, PPP1R87, SMN2, Tg(SMN2)89Ahmb |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grm7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- Periplasmic binding protein
- G beta gamma protein binding domain
- enzyme inhibitor activity
- glutamate binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- adenylate cyclase inhibiting metabotropic glutamate receptor
- ligand-binding domain
- Type 1 periplasmic binding fold superfamily
- loop domain
- G-protein coupled receptor
- extracellular domain
- calcium-dependent protein binding
- Receptor family ligand binding region
- calmodulin binding
- calmodulin binding domain
- calcium ion binding
- enzyme regulator activity
- protein binding
- calcium channel regulator
- glutamate receptor
- PDZ-domain binding
- amino acid binding
- voltage-gated calcium channel
- binding protein
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- PDZ binding motif
- group III metabotropic glutamate receptor
Pathways
Biological processes and signaling networks where the Grm7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Glutamate Receptor Signaling
- Gαi Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Phagosome Formation
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities
- schizophrenia
- myopia
- breast carcinoma
- convulsion
- colorectal cancer
- panic disorder
- leprosy
- insomnia
role in cell
- apoptosis
- number
- development
- transmission
- activation
- outgrowth
- long-term potentiation in
- outgrowth in
- long term synaptic depression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic active zone
- glutaminergic synapse
- cell surface
- intracellular space
- cellular membrane
- cell cortex
- Endoplasmic Reticulum
- apical cell surfaces
- basolateral cell surfaces
- presynaptic membrane
- postsynaptic membrane
- synaptic vesicles
- growth cone
- neurites
- nerve ending
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- dendritic shafts
- basement membrane
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grm7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- glycosylation
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- negative regulation of glutamate secretion
- synaptic transmission
- G-protein coupled glutamate receptor signaling pathway
- regulation of synaptic transmission, glutamatergic
- behavioral fear response
Cellular Component
Where in the cell the gene product is active
- dendrite
- presynaptic active zone
- postsynaptic membrane
- cell cortex
- dendritic shaft
- membrane
- asymmetric synapse
- receptor complex
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- serine binding
- group III metabotropic glutamate receptor activity
- glutamate receptor activity
- adenylate cyclase inhibitor activity
- protein dimerization activity